Rajiv
Gandhi Proudyogiki Vishwavidalaya, Bhopal (M.P.)
B.
PHARMA-VI SEMESTER (Modified on 03/09/12)
Pharmaceutical
Industrial Management PY-601
Status of pharmaceutical
industries in India.
Project formulation, evaluation
and implementation.
Pharmaceutical Factory Planning
and layouts, preparation of flow diagrams, technical
data sheets.
Pharmaceutical
Management :
Concepts on Management,
Principles of Management, Administrative and
Operative Management
Enterpreneurship Development.
Material management: Basic
principles of Material Management, Purchase, Store and
Inventory control.
Pharmaceutical
Production Management :
Different aspects of Production
Management , Performance Evaluation Technique,
flow-process, know how process
and maintainence.
Accountancy: Principles of
accountancy, Journal entries and ledger posting, preparation
of trial balance, cash book, bank
reconciliation statement, rectification of errors, profits
and loss account, balance sheet,
purchase, keeping and pricing of stocks, treatment of
cheques, bill of exchange,
promissory notes and hundies, documentary bills.
Pharmaceutical
Economics:
Principles of economics with
special reference to the laws of demands and supply,
demand schedule, demand curves,
general principles of insurance and inland and foreign
trade, procedure of exporting and
importing goods.
Pharmaceutical Marketing:
Functions, wholesale, retail, and mail order business ,market
research.
Pharmaceutical
Salesmanship:
Principles of sales promotion,
advertising, and ethics of Sales, merchandising, Window
display and literature detailing.
BOOKS
RECOMMENDED:
1. Shukla, S. M., Advanced
Accountancy, Mahershwari Sahitya Bhawan, Agra.
2. Gupta, R. L., Advanced
Accountancy, Vol. I and II, Sultanchand & Company, New Delhi.
3. Kotler, P., Marketing
Management, Prentice Hall of India Limited.
4. Stanton, W. J., Fundamentals
of Marketing Tata McGraw Hill Limited, New Delhi.
5. Buskir K. and Richard H.,
Principles of Marketing – The Management View, Hold
Rinehard and Winston
Incorporated, New York.
6. Sherlekar, S. R., Marketing
Management, Himalaya Publishing House, New Delhi.
7. Mote,V. L., Paul, S. and
Gupta, G. S., Managerial Economics Concepts and Cases,
Tata McGraw Hill Limited, New
Delhi.
Pharmaceutical
Analysis II - PY 602
The theoretical aspects, basic
instrumentation, elements of interpretation of
spectra and pharmaceutical
application of the following analytical techniques –
1. Chromatography: Paper
Chromatography TLC, GLC, HPTLC and HPLC.
2. Ultraviolet and visible
spectrophotometry: Beer-lambart law, electronic
transitions, instrumentation,
methods, chemical derivatisation, structural analysis,
applications.
3. Infra red spectrophotometry
& FT-IR: Introduction, Theory, instrumentation,
interpretation of spectra, its
advantages and applications in structure elucidation.
4. Fluorimetry.
5. Mass Spectroscopy:
Introduction, ionization techniques, mass analyzers,
fragmentation rules,
instrumentation, the mass spectrum & its applications.
6. NMR Spectroscopy:
Introduction, continous-wave (CW) NMR spectrometry,
pulsed fourier transform
spectrometry, chemical shift, spin coupling, spin
decoupling & its
applications.
7. Atomic Absorption.
8. X- Ray Diffraction.
9. Flame Photometry.
10. Immunoassay techniques:
Enzymes & radioimmunoassay techniques, theory,
methods & its applications.
BOOKS
RECOMMENDED:
1. Svehla, G. Vogel’s Text Book
of Micro and Semi Micro Qualitative Inorganic
Analysis, Orient Longman,
Hyderabad.
2. Beckett, A.H. and Stenlake,
J.B., Practical Pharmaceutical Chemistry, The
Athlone Press of the University
of London.
3. Chatten, L.G., Text Book of
Pharmaceutical Chemistry, Marcel Dekker, New
York.
4. Connors, K,.A., A Text Book of
Pharmaceutical Analysis, Wiley Interscience,
New York.
5. Higuchi, J. and Hansen E.B.,
Pharmaceutical Analysis, Interscience Publisher
John Willey and Sons, New York,
Sydney.
6. Silverstein,R.M., Bassier,
G.C., and Morril,T.C., Spectrophotometric
Identification of Organic
Compounds, John Wiley and Sons Inc.
7. Willard, Merritt and Settle,
Instrumental Methods of Chemical Analysis,CBS
Publisher and Distributors, New
Delhi.
8. Ewing, G.W., Instrumental
Methods of Chemical Analysis,.
LIST OF
PRACTICALS :
1. Determination of solvent cut
off value of different solvents.
2. Study of effect of various
solvents on spectral features of any drug.
3. Perform the quantitative
spectrophotometric estimation of drug by single
point method.
4. Perform the quantitative
spectrophotometric estimation of drug by
calibration curve method.
5. Perform the quantitative
spectrophotometric estimation of drug by
standard absorptivity method.
6. Simultaneous quantitative
spectrophotometric estimation of two drugs by
simultaneous equation method.
7. Simultaneous quantitative
spectrophotometric estimation of two drugs by
dual wavelength method.
8. Simultaneous quantitative
spectrophotometric estimation of two drugs by
derivative spectroscopy.
9. To determine the tablet
content of norfloxacin by hydrotrophy.
10. Interpretation of given IR
spectra.
11. Quantitative estimation of
alprazolam (Any drug) by RP-HPLC.
12. Simultaneous quantitative
estimation of torsemide and spironolactone
( Combination of two drugs) by
RP-HPLC.
13. Acid and alkaline stress
degradation study of any drug.
14. Photo and thermal stress
degradation study of any drug.
15. Oxidative stress degradation
study of any drug.
PHARMACEUTICAL
CHEMISTRY – VII PY-603 (MEDICINAL CHEMISTRY-II)
( I )
Classification and mode of action, uses, structure activity relationship
including
physicochemical,
steric aspects and recent advances in research of the following
categories of
drugs:
(A) Drug Acting
on CNS
* General Anesthetics: Stages of
Anesthesia , Pharmacokinetic Principles,
Theories of the mechanisms.
*Hypnotics and
Sedatives : Testing and developments of new Hypnotics.
* Antiscizure agents: Drugs effective
against partial and generalized tonicclonic
scizure.
* Opiod Analgesics : Endogenous opioid
peptides and their physiologic
functions, Neurobiology of drug
abuse and addiction.
* Antiparkinsonian and Spasmolytic agents
: Pharmacotherpy of Parkinsons
disease.
* Hallucinogens, Stimulants, and related
drugs of Abuse.
* Psychopharmacological Agents:
Antipsychotic agents, Antidepressants,
Anxiolytics.
(B) Drug Acting
on GIT :
* Laxative
* Antidiarrhoeal
* Anti spasmodic
* Antiulcers Drugs.
(C) Drug Acting
on Hormonal System:
* Insulin and oral Hypoglycemic agents:
Etiology of Diabetes, Biochemistry
and Pathogenesis of Diabetes,
Production of Insulin.
* Adrenocorticoids: Mechanism of steroid
Hormone action, Development of
Adrenocorticoid drugs.
* Sex Hormones: Male sex Hormones, Female
sex Hormones.
* Thyroid and Antithyroid agents :
Biochemistry and Physiology of Thyroid
Hormones, Biosynthesis of Thyroid
Hormones.
(D) Vitamins
( II )
Principles of Drug Design (Theoretical Aspects). Scientific Aspects of Drug
Discovery,
Preclinical Development, Mechanism based Approaches (Computer
Aided Drug
Design and Molecular Modeling)
BOOKS
RECOMMENDED:
1. Foye, W.C., Principles of
Medicinal Chemistry, Lea and Febiger,
Philadelphia.
2. Wolff , M.E. Ed., Burger’s
Medicinal Chemistry, John Wiley and Sons,
New York.
3. Hansch, C., Comprehensive
Medicinal Chemistry, Pergarnon Press,
Oxford.
4. Delagado, J.N. and Remers,
W.A.R, Wilson and Giswold’s Text Book of
Organic,Medicinal and
Pharmaceutical Chemistry, J.Lippincott Co.,
Philadelphia.
5. Nogrady, T., Medicinal
Chemistry-A Biochemical Approach, Oxford
University Press, New York,
Oxford.
6. Kar, A., Medicinal Chemistry,
Willey Eastern Ltd., New Delhi.
7. Patrick, G., An Introduction
to Medicinal Chemistry, Scientific
Distributors, Mumbai.
8. Malone, Dyson and Purey, May’s
Chemistry of Synthetic Drugs.
9. Parimoo, P., Text Book of
Medicinal Chemistry, CBS Publishers and
Distributors, New Delhi.
10. Thomas, G., Introduction to
Medicinal Chemistry, CBS Publishers and
Distributors, New Delhi.
LIST OF
PRACTICALS :
1. Synthesis and Characterization
of Methylphenobarbital from Urea.
2. Synthesis and Characterization of
Barbital from Urea.
3. Synthesis and Characterization of
Nikethamide from Nicotinic acid.
4. Synthesis and Characterization of
Pantaprazol.
5. Synthesis and Characterization of
Diclofenamide.
6. Synthesis and Characterization of
Phenobarbitone.
7. Synthesis and Characterization of
Phenothiazine.
8. Synthesis and Characterization of
Furosemide from 2,4 dichloro-benzoic acid.
9. Synthesis and Characterization of
Levodopa from Vanillin.
10. Synthesis and Characterization of
Sulfalene from p-aminobenzene sulphonyl
chloride.
11. Synthesis and Characterization of
Thioridazine.
12. Synthesis and Characterization of
Chlorpromazine.
13. Synthesis and Characterization of
Benorilate.
14. Synthesis and Characterization of
Parbanic acid.
15. Estimation of Na+, K+, Ca++ ions using flame
photometry.
16. To perform the QSAR Analysis by
Free Wilson Approach.
17. To determine the regression
coefficients for a series by using Hansch and Free
Wilson Approach.
18. To determine the correlation
between physiochemical properties and biological
activity for a series by using
Hansch analysis.
PHARMACOGNOSY
– IV (PY
604)
General introduction
classification and brief description of different chromatographic
techniques with detailed emphasis
on application of paper chromatography, column
chromatography, TLC, HPLC and
HPTLC in the evaluation of herbal drugs.
Historical development of plant
tissue culture technique, types of culture, nutritional
requirements, surface
sterilization of explants, growth and maintenance. Application of
PTC in development of
phytoconstituents.
An introduction of marine
pharmacognosy and novel agents from marine sources like
cardiovascular active substances,
cytotoxic, antimicrobial, antibiotic, anti-inflammatory,
antispasmodic agents, marine
toxin etc.
Herbs as health food,
cosmeceuticals.
An introduction to cultivation
and utilization of aromatic plants with special reference to
sandalwood oil, menthe oil,
eucalyptus oil, lemon grass oil, clove oil.
Production and analysis of
phytoconstituents of pharmaceutical importance like quinine,
strychnine, atropine, morphine
podophyllotoxin, papain, vincristine, ephedrine and
Tannic acid, Spectral analysis of
herbal drugs with emphasis on application of UV, IR,
NMR, mass.
Natural dyes, Immunomodulators
and Adaptogents.
LIST OF
PRACTICAL:
1. To perform
chromatography of amino acids
2. To
perform paper chromatography of sugars
3. To perform TLC of alkaloids
4. To perform TLC of extract of
rauwolfi, datura
5. To perform TLC of volatile
oils i.e. eucalyptus oil, menthe oil
6. To identify the presence of
eugenol in clove oil by TLC
7. To determine volatile oil
content of eucalyptus leaf
8. To determine volatile oil
content of fennel fruits
9. To isolate ammonium
glycyrrhizinate from glycyrrhiza
10. To extract aloin from aloe
11. To extract tannic acid from
myrobalan
12. To perform column
chromatography a natural dye.
BOOKS
RECOMMENDED:
1. Trease, G.E.and Evans, W.C.,
Pharmacognosy, Baillierc, Tindall, Eastbourne,
U.K.
2. Tayler, V.E., Brady, L.R. and
Robers, J.E., Pharmacognosy Lea and Febiger,
Philadelphia
3. Kokate, C.K., Purohit, A.P.
and Gokhale, S.B., Pharmacognosy Nirali Prakashan,
Pune
4. C.R Atal and B.M. Kapoor,
Cultivation & Utilization of Aromatic Plants, Council
of Scientific Industrial Research
(CSIR) New Delhi.
Pharmacology-III
(PY 605)
Pathophysiology
of diseases of cardiovascular system and pharmacology of drugs
used for their
treatment
a) Cardiac Glycosides
b) Antiarrythmic drugs
c) Antianginal drugs
d) Antihypertensive drugs
Pharmacology of
drugs acting on hematopoietic system
a) Hematinics
b) Drugs affecting coagulation,
bleeding and thrombosis
c) Plasma expanders
d) Hypolipidaemic drugs
Pharmacology of
drugs acting on urinary system
Pathophysiology
of diseases of endocrine system and pharmacology of drugs used
for their
treatment
a) Hypothalamic and pituitary
hormones
b) Thyroid hormones and
antithyroid drugs
c) Insulin, oral hypoglycemic
agents and glucagons
d) Corticosteroids
e) Androgens and drugs for
erectile dysfunction
f) Estrogens, progestins and
contraceptives
g) Oxytocin and drugs acting on
uterus
h) Drugs affecting calcium
balance
List of
Practicals
1. Determine the strength of
given sample (acetyl choline/ histamine) by three point
bioassay method using isolated
organ preparation (rat ileum/ rat duodenum/ rat colon/
rat fundus/ guinea pig ileum).
2. Determine the strength of
given sample (acetyl choline/ histamine) by four point
bioassay method using isolated
organ preparation (rat ileum/ rat duodenum/ rat colon/
rat fundus/ guinea pig ileum).
3. Record the concentration
response curve of oxytocin using rat uterus preparation.
4. Determine the sympatholytic
activity of given drug sample using isolated guinea pig
ileum preparation.
5. Compare the diuretic/saluretic
activity of different drugs in rats.
6. Determine the effect of
anticoagulants by subaqueous tail bleeding time method in
rodents.
7. Study the effect of oral
hypoglycemic agents in diabetic rodents.
8. Study the effect of thyroid
hormones on the tensile strength of connective tissues in
rats.
9. Study the effect of growth
hormone on the weight gain in female rats.
BOOKS
RECOMMENDED
1) Herfindal, E.T., Gourley,
D.R., (eds.) (2000) Textbook of therapeutics Drug and
disease management. 7th ed. Baltimore:
Lippincott Williams and Wilkins
2) Hardmen, J.G., Limbird, L.E.,
Gilman A.,G., (eds.) (2001) Goodman and Gilman’s
The pharmacological basis of
therapeutics. 10th
ed.
USA: The McGraw Hill Companies
3) Kumar, V., Abbas, A.K.,
Fausto, N., (eds.) (2004) Robbins and Cotran Pathologic
basis of disease. 7th ed. Pennsylvania:
Saunders
4) Barar, F.S.K., (2000)
Essentials of therapeutics. New Delhi: S. Chand and Company
(P) Ltd.
5) Satoskar, R.S., Bhandarkar,
S.D., Rege, N.N., (2007) Pharmacology and
Pharmacotherapeutics. 12th ed. Mumbai:
Popular Prakashan
6) Seth, S.D., (ed.) (2005)
Textbook of Pharmacology. 2nd ed. New Delhi. Elsevier
7) Tripathi, K.D. (1999)
Essentials of medical pharmacology. 4th ed. New Delhi: Jaypee
Brothers Medical Publishers (P)
Ltd.
8) Rang, H.P., et al. (eds.)
(2003) Pharmacology. 5th
ed.
Philadelphia: Elsevier
9) Katzung, B.G., (2004) Basic
and clinical pharmacology. 9th ed. USA: The McGraw
Hill Companies.
10) Pillai, K.K., (2009)
Experimental Pharmacology. New Delhi, CBS Publishers and
Distributers.
11) Kulkarni, S.K., (2005)
Handbook of Experimental Pharmacology. New Delhi,
Vallabh Prakashan.
12) Vogel, H.G., (ed.) (2002)
Drug Discovery and Evaluation. Pharmacological Assays.
2nd Ed. Heidelberg,
Germany, Springer-Verlag.
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