Aromatic waters are clear aqueous solution saturated with volatile Oils (e.g. rose oil, Peppermint oil, orother aromatic or volatile substances eg. camphor. Their odours and taste are of those of the drugs or
volatile substances from which they are prepared.
Aromatic waters may be used for perfuming, . avoring or for special purposes for eg.
1. Camphor water has been used as the vehicle in ophthalmic solutions owning to its ability to contribute
refreshing, stimulating effect to the preparation.
2. Hamamelis water known as witch hazel is employed as a rub, perfume and as an astringent in
various cosmetic preparations, particularly in after-shave lotions.
1.Distillation Method:
The distillation method involves the placing of the coarsely ground odoriferous portion of the plant
or drug from which the aromatic water is to be prepared in a suitable still, with suf. cient puri. ed
water. Most of the volume of water is then distilled. The excess oils collected with the distillate rises
to the top of the aqueous product and are removed. The remaining aqueous solutions, saturated
with volatile material require clari. cation by . ltration.
2. Solution Method:
Aromatic water is prepared by intermittently shaking 2ml (if liquid) or 2gm (if solid) of the volatile
substance with 1000ml of puri. ed water in suitable container for period of 15 minutes. After the
period of agitation the mixture is set aside for 12 hours or longer to permit the excess oil and the
solid substance to settle. Without further agitation the mixture is passed through a wetted . lter
paper and puri. ed water added as needed to bring the volume of the . ltrate upto the prescribed
quantity.
3.Alternative solution Method:
By this method the volatile oil or suitably comminuted aromatic solid is thoroughly incorporated
with 15gms of talc and to this mixture is added 1000ml of puri. ed water. The resulting slurry is
thoroughly agitated several times for the period of 30 minutes and then . ltered.
Preparation of concentrated Aromatic water:
These products are alcoholic non aqueous preparations containing 2% of volatile oils They are forty
times stronger than the ordinary aromatic waters. Many volatile oils contain aromatic part and non-aromatic
part. The aromatic portion is much more soluble in a weak alcohol than the non-aromatic portion.
Hence when a solution of the oil in 90% alcohol is diluted with a limited amount of water the aromatic portion
of the oil remains in solution while the non-aromatic portion is precipitated off, separating as an oily
layer. Therefore 50gms of talc is added for 1000ml of preparation which acts as a distributing agent, and
will absorbs the non-aromatic part. The solution is agitated and set aside for a few hours and . ltered.
Storage: Aromatic water deteoriate with time and it should be made in small quantities and protected
from intense light and excessive heat and stored in airtight, light resistance container.
Note for teacher: Any other of. cial aromatic water can be done beside the preparation given in the
manual for these experiments
volatile substances from which they are prepared.
Aromatic waters may be used for perfuming, . avoring or for special purposes for eg.
1. Camphor water has been used as the vehicle in ophthalmic solutions owning to its ability to contribute
refreshing, stimulating effect to the preparation.
2. Hamamelis water known as witch hazel is employed as a rub, perfume and as an astringent in
various cosmetic preparations, particularly in after-shave lotions.
1.Distillation Method:
The distillation method involves the placing of the coarsely ground odoriferous portion of the plant
or drug from which the aromatic water is to be prepared in a suitable still, with suf. cient puri. ed
water. Most of the volume of water is then distilled. The excess oils collected with the distillate rises
to the top of the aqueous product and are removed. The remaining aqueous solutions, saturated
with volatile material require clari. cation by . ltration.
2. Solution Method:
Aromatic water is prepared by intermittently shaking 2ml (if liquid) or 2gm (if solid) of the volatile
substance with 1000ml of puri. ed water in suitable container for period of 15 minutes. After the
period of agitation the mixture is set aside for 12 hours or longer to permit the excess oil and the
solid substance to settle. Without further agitation the mixture is passed through a wetted . lter
paper and puri. ed water added as needed to bring the volume of the . ltrate upto the prescribed
quantity.
3.Alternative solution Method:
By this method the volatile oil or suitably comminuted aromatic solid is thoroughly incorporated
with 15gms of talc and to this mixture is added 1000ml of puri. ed water. The resulting slurry is
thoroughly agitated several times for the period of 30 minutes and then . ltered.
Preparation of concentrated Aromatic water:
These products are alcoholic non aqueous preparations containing 2% of volatile oils They are forty
times stronger than the ordinary aromatic waters. Many volatile oils contain aromatic part and non-aromatic
part. The aromatic portion is much more soluble in a weak alcohol than the non-aromatic portion.
Hence when a solution of the oil in 90% alcohol is diluted with a limited amount of water the aromatic portion
of the oil remains in solution while the non-aromatic portion is precipitated off, separating as an oily
layer. Therefore 50gms of talc is added for 1000ml of preparation which acts as a distributing agent, and
will absorbs the non-aromatic part. The solution is agitated and set aside for a few hours and . ltered.
Storage: Aromatic water deteoriate with time and it should be made in small quantities and protected
from intense light and excessive heat and stored in airtight, light resistance container.
Note for teacher: Any other of. cial aromatic water can be done beside the preparation given in the
manual for these experiments
1 Title: To prepare, evaluate and submit 100ml of Chloroform Water I.P. by Simple Solution Method.
(Read the Introduction of Aromatic Waters.)
2.purpose Different types of solutions, volumetric measurement
3.New concepts: Proposition 1: Pharmaceutical Aid
Preparation used as an excipient or base or vehicle for formulation of other pharmaceutical
preparations.
Proposition 3: Storage: Aromatic waters are stored in air tight, light resistant container.
4 Apparatus: Glass Beaker (250 ml), Volumetric Cylinder (100 ml), Volumetric Pipette (1ml).
5 Step wise procedure:
It is saturated solution of chloroform in puri. ed water .The solubility of chloroform is 1 in 800 parts
of water.
1. Measure the required quantity of chloroform.
Pharmaceutics - I Experiment No. 3
2. Add suf. cient quantity of puri. ed water to make the required volume with constant stirring
so that chloroform gets uniformly mixed.
Dose: 15 to 30 ml
Category: Pharmaceutical Aid.
Storage: store in airtight container in cool place away from light.
7 Labeling of formulation:
(Students shall write all aspects of labeling in the space provided below.)
8 Observation and evaluation:
9 Result:
…………ml of ………………………………………………………………………….. preparation is
submitted in ……………………………………………. container with neat label.
(Read the Introduction of Aromatic Waters.)
2.purpose Different types of solutions, volumetric measurement
3.New concepts: Proposition 1: Pharmaceutical Aid
Preparation used as an excipient or base or vehicle for formulation of other pharmaceutical
preparations.
Proposition 3: Storage: Aromatic waters are stored in air tight, light resistant container.
4 Apparatus: Glass Beaker (250 ml), Volumetric Cylinder (100 ml), Volumetric Pipette (1ml).
5 Step wise procedure:
It is saturated solution of chloroform in puri. ed water .The solubility of chloroform is 1 in 800 parts
of water.
1. Measure the required quantity of chloroform.
Pharmaceutics - I Experiment No. 3
2. Add suf. cient quantity of puri. ed water to make the required volume with constant stirring
so that chloroform gets uniformly mixed.
Dose: 15 to 30 ml
Category: Pharmaceutical Aid.
Storage: store in airtight container in cool place away from light.
7 Labeling of formulation:
(Students shall write all aspects of labeling in the space provided below.)
8 Observation and evaluation:
9 Result:
…………ml of ………………………………………………………………………….. preparation is
submitted in ……………………………………………. container with neat label.
No comments:
Post a Comment