Thursday, January 29, 2009

CALAMINE LOTION USP
FORMULA

CALAMINE :80g
Zinc oxide 80g
Glycerin 20ml
Bentonite magma 250mL
Calcium hydroxide q.s. 1000mlTopical solution

PROCEDURE:

Dilute the bentonite magma with an equal volume of calcium hydroxide topical solution mix the power intimately with the glycerin and about 100ml of the diluted magma .triturating until a smooth ,uniform paste is formed .gradually in corporate the remainder of the diluted magma .finally add enough calcium hydroxide topical solution to make 1000ml and shake well .if a more viscous consistency in the lotion to not more than 400ml
Many investigator have studied calamine lotion ,and this has led to the satisfying the collective needs of all dermatologists

THEORY:

A lotion is a low- to medium-viscosity, topical preparation intended for application to unbroken skin; creams and gels have a higher viscosity. Most lotions are oil-in-water emulsions, but water-in-oil lotions are also formulated. Lotions are usually applied to external skin with bare hands, a clean cloth, cotton wool or gauze; creams and gels usually only with one's fingers or palms. Many lotions, especially Hand Creams and Face cream are formulated not as a medicine delivery system, but simply to smooth and soften the skin— these are particularly popular with the aging and aged demographic groups, and in the case of face usage, can also be classified as a cosmetic in many cases.The key components of a skin care lotion, cream or gel emulsion (that is mixtures of oil and water) are the aquous and oily phases, an emulgent to prevent separation of these two phases, and, if used, the drug substance or substances. A wide variety of other ingredients such as fragnances, glycerol, petrolium jelly, dyes, preservatives proteins and stabilizing agents are commonly added to lotions.

USES:

Calamine is a mixture of ZINC OXIDE (ZnO) with about 0.5% IRON OXIDE(Fe2O3).
CALAMINE is the main ingredient in calamine lotion and is used as an ANTIPRURITIC (anti-itching agent) to treat mild pruritic conditions such as SUNBURN , ECZEMA , RASHES, POISON IVY , CHICKEN POX ,
 INSECT bites and stings.It is also used as a mild ANTISEPTIC to prevent infections that can be caused by scratching the affected area, and an ASTRINGENT to dry weeping or oozing BLISTERS and ACNE ABSCESSES.

 IT ALSO ACT AS SOOTHING,SMOOTHING AND MOISTURING AGENT AND GIVES PROTECTION FROM SUNBURN



Remington sciences & practice page no 772-773

4 comments:

  1. Glycerin can be used in food, beverage, and medical applications.

    ReplyDelete
  2. thank you so much..i will doing this for my next semi solid lab practice.

    ReplyDelete
  3. where does the Fe2O3 come from in your formula? Is the 0.5%, 0.5% of the Zinc Oxide weight? or the weight of the lotion?

    ReplyDelete