Formulation and evaluation of mucilage based matrix tablets of Lamivudine

Formulation and evaluation of mucilage based matrix tablets of

Lamivudine

The present investigation is aimed at formulating and evaluating Mucilage based sustained release

matrix tablets of Lamivudine using different natural polymers such as Guar Mucilage, Xanthan Mucilage,

Rosin Mucilage, Pectin, and Sodium alginate taken at 30%, 40% and 50% of the total weight of the

tablet. Lamivudine is a potent hydrophilic anti viral agent indicated for treatment of AIDS

(Acquired Immunodeficiency Syndrome). It was found that the cumulative percent drug release

decreased with increasing concentration of natural Mucilages. All the formulations were able to

retard the release of the drug beyond 18 hours except pectin and sodium alginate were unable to

sustain the drug release from the matrix tablets. F5 (40% Xanthan Mucilage) formulation was

selected as optimized formulation. The swelling study states that the swelling index was

increased up to 6 hours and there after that the swelling index was decreased. No chemical

interaction between Drug and the Mucilage were seen as confirmed by FT-IR studies. Thus, sustained

release matrix tablets of Lamivudine using natural Biodegradable and biocompatible polymers

were successfully formulated, evaluated and found to be suitable candidates in extending the

release of the drug from the matrix tablets.